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Antigenic variation of hundreds of respiratory viruses result in repeated circulation in the community.A coryza syndrome is by far the most common cause of physician visits in the United States.

Onset of symptoms occurs 1 to 3 days after exposure to the infectious agent.Back to Top Transmission of organisms causing URIs occurs by aerosol, droplet, or direct hand-to-hand contact with infected secretions, with subsequent passage to the nares or eyes.Thus, transmission occurs more commonly in crowded conditions.Influenza epidemics occur every year between November and March in the Northern Hemisphere.

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Approximately two thirds of those infected with influenza virus exhibit clinical illness, 25 million seek health care, 100,000 to 200,000 require hospitalization, and 40,000 to 60,000 die each year as a result of related complications.

Back to Top Most URIs occur more frequently during the cold winter months, because of overcrowding.

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